PTM-Switchboard—a database of posttranslational modifications of transcription factors, the mediating enzymes and target genes

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PTM-Switchboard—a database of posttranslational modifications of transcription factors, the mediating enzymes and target genes

Gene transcription is largely regulated by sequence-specific transcription factors (TFs). The TF activity is significantly regulated by its posttranslational modifications (PTMs). TF-PTMs serve as 'molecular switchboards' that map multiple upstream signaling events, in response to various environmental perturbations, to the downstream transcriptional events. While many instances of TF-PTMs and ...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2008

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/gkn731